Literature

Alcor

2025

Schottdorf, Manuel, et al

TWINKLE: An open-source two-photon microscope for teaching and research

TWINKLE is a fully open, low-cost two-photon microscope for neuroscience teaching and research, with performance comparable to commercial systems.

PloS one

Alcor

2025

Leong, L.M., Shin, S.C., Frankiv, N., Rhee, J.K., Kim, H., Seong, J., Woo, J., Han, K., Storace, D.A. and Baker, B.J.

Modulating Chromophore Flexibility in GEVIs through Threonine-Based Molecular Switches Reveals an Influence of Membrane Curvature on Protein Activity

Threonine-based molecular switches modulate chromophore flexibility in genetically encoded voltage indicators, revealing membrane-curvature effects on protein activity assessed by two-photon imaging.

ACS Sensors

Alcor

2025

Estaún-Panzano, J., Dembitskaya, Y., Calaresu, I., Nandi, S., Gresil, Q., Doudnikoff, E., Leste-Laserre, T., Amédée, T., Cognet, L., Groc, L. and Nägerl, U.V

Decoding Amyloid Plaque Penetrability: Exploring Extracellular Space and Rheology in Plaque-rich Cortex

Two-photon shadow imaging and quantum-dot tracking reveal extracellular-space rheology and amyloid-plaque penetrability in a mouse model of Alzheimer's cortex.

bioRxiv

Alcor

2025

Yang, M., Zhou, Z.Q., Lang, S., Zheng, H., Chen, S., Li, T., Stas, E., Yu, J., Zhang, L., Zhang, Z. and Uzungil, V.

Ultra-wide-field, deep, adaptive two-photon microscopy

ULTRA, a two-photon microscope with 50 mm² field of view, enables single-cell resolution imaging across widely distributed superficial and deep cortical regions.

bioRxiv

Alcor

2025

Hira, R., Imamura, F., Imamura, H., Yoneyama, Y., Handa, T., Fujioka, O., Yu, C.H., Suitoh, S., Hira, R., Kamoshida, A. and Kato, S

Open-source modular FPGA system for two-photon mesoscope enabling multi-layer, multi-depth neural activity recording and lifetime imaging

An FPGA system digitising photomultiplier signals at 3.2 GS/s enables fast, multi-layer, multi-depth calcium and fluorescence-lifetime imaging with two-photon mesoscopes.

bioRxiv

Alcor

2025

Liu, X., Uchigashima, M., Oomoto, I., Saito, Y., Uchida, H., Oginezawa, S., Masuda, K., Satoh, D., Abe, M., Sakimura, K. and Shimizu, Y

SeeThrough: a rationally designed skull clearing technique for in vivo brain imaging

SeeThrough, a rationally designed refractive-index-matching solution, clears the intact mouse skull to enable high-resolution two-photon brain imaging without craniotomy.

Nature Communications